What is DAA - D-Aspartate - ABCbodybuilding

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  #1  
Old 11-26-2010, 11:48 AM
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Default What is DAA - D-Aspartate

D-Aspartate:

This amino acid is naturally found in high quantities in the reproductive organs, hypothalamus and pituitary. Through a methyl-transferase reaction called NMDA sythethetase, D-Aspartic Acid is converted into N-Methyl-D-Aspartate, which is a potent stimulator of the N-Methyl-D-Aspartate Receptor pathway. D-Aspartate is found in the hypothalamus, pituitary and testis in extremely high quantities during periods of heightened physical and sexual maturation. Considered by Muscle Warfare researchers as the master amino acid hormonal regulator, oral ingestion results in heightened hGH, GhRH, Testosterone, LhRH, IGF-1 and IGF-2 levels.

D-Aspartate, via steroidogenic pathways, enhances all aspects of sexual performance as well as the development of body weight gain via lean muscle mass development. D-Aspartate also induces potent elevation of neurotransmitters such as dopamine & GABA, which are implicated to be responsible for its memory enhancing, anti-depressive & nootropic effects. D-Aspartic Acid is found naturally in cheeses and meat and also converted from L-Aspartic Acid via the aspartate racemase enzyme.

A welcome side effect often reported with use should be noted. Due to the profound hormonal increase and simultaneous stimulation of the N-Methyl-D-Aspartate Receptor, D-Aspartic Acid is a very potent sexual performance stimulator, enhancing libido, erection quality, ejaculate, duration of intercourse and perceived orgasm intensity.

(NMDA actually compared to apomorphine in some studies with relation to its erection enhancing effects. Our beta testers were loving this stuff. Some comparing it to prescription stuff, but without the stuffy nose and blurry vision... plus more "drive"...)

Here is some validation... check it out...

"Int J Impot Res. 2000 Oct;12(5):255-62.

EP 60761- and EP 50885-induced penile erection: structure-activity studies and comparison with apomorphine, oxytocin and N-methyl-D-aspartic acid.

Melis MR, Spano MS, Succu S, Locatelli V, Torsello A, Muller EE, Deghenghi R, Argiolas A.
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.

The effect of 10 peptides structurally related to the growth hormone (GH) releasing peptide hexarelin, injected into the paraventricular nucleus of the hypothalamus (PVN), on penile erection was studied in male rats. Six out of the 10 peptides tested induced penile erection in a dose-dependent manner. Among them, the most potent were EP 80661, EP 60761 and EP 91072, which were active at doses of 20-200 ng. The potency of these peptides in inducing penile erection is comparable to that of apomorphine, oxytocin and N-methyl-D-aspartic acid similarly injected into the PVN. Other peptides found active were EP 50885, EP 90101 and EP 91071, which induced penile erection at doses of 200-2000 ng. In contrast, EP 51322, EP 70555, EP 51216 and EP 91073 were inactive, as were hexarelin, EP 40904 and EP 40737 in a previous study. The majority of EP peptides found active when injected into the PVN induced penile erection, although to a lesser extent, also when given systemically (endovenously). The proerectile effect of EP peptides was prevented by the oxytocin receptor antagonist [d(CH2)5 Tyr(Me)2-Orn8]-vasotocin given into the lateral ventricles but not into the PVN, by the nitric oxide (NO) synthase inhibitor N(G)-nitro-1-arginine methyl ester given either into the lateral ventricles or into the PVN, by the N-type Ca2+ channel blocker omega-conotoxin GVIA and by morphine, but not by the dopamine receptor antagonist cis-flupenthixol or by the N-methyl-D-aspartic acid receptor antagonist dizolcipine, given into the PVN. As the structure-activity relationship of EP peptides for proerectile activity is different from those of other biological actions of these compounds, ie for GH release and eating behaviour, the present results suggest that EP peptides induce penile erection by acting on specific hypothalamic receptor sites that activate paraventricular oxytocinergic neurons projecting to extrahypothalamic brain areas that mediate this sexual function by a mechanism similar to that of dopamine receptor agonists, oxytocin and N-methyl-D-aspartic acid."


some more fun facts......


Prog Neurobiol. 2005 May;76(1):1-21.

Central control of penile erection: role of the paraventricular nucleus of the hypothalamus.

Argiolas A, Melis MR. Bernard B. Brodie Department of Neuroscience, Centre of Excellence for the Neurobiology of Addictions, University of Cagliari, S.P. Sestu-Monserrato Km 0.700, 09042 Monserrato, Cagliari, Italy. argiolas@unica.it

The paraventricular nucleus of the hypothalamus is an integration centre between the central and peripheral autonomic nervous systems. It is involved in numerous functions from feeding, metabolic balance, blood pressure and heart rate, to erectile function and sexual behaviour. In particular, a group of oxytocinergic neurons originating in this nucleus and projecting to extra-hypothalamic brain areas (e.g., hippocampus, medulla oblongata and spinal cord) control penile erection in male rats. Activation of these neurons by dopamine and its agonists, excitatory amino acids (N-methyl-D-aspartic acid) or oxytocin itself, or by electrical stimulation leads to penile erection, while their inhibition by gamma-amino-butyric acid (GABA) and its agonists or by opioid peptides and opiate-like drugs inhibits this sexual response. The activation of these neurons is secondary to the activation of nitric oxide synthase, which produces nitric oxide. Nitric oxide in turn causes, by a mechanism that is as yet unidentified, the release of oxytocin in extra-hypothalamic brain areas. Other compounds recently identified that facilitate penile erection by activating central oxytocinergic neurons are peptide analogues of hexarelin, a growth hormone releasing peptide, pro-VGF-derived peptides, endogenous peptides that may be released by neuronal nerve endings impinging on oxytocinergic cell bodies, SR 141716A, a cannabinoid CB1 receptor antagonist, and, less convincingly, adrenocorticotropin-melanocyte-stimulating hormone (ACTH-MSH)-related peptides. Paraventricular oxytocinergic neurons and similar mechanisms are also involved in penile erection occurring in physiological contexts, namely noncontact erections that occur in male rats in the presence of an inaccessible receptive female, and during copulation. These findings show that the paraventricular nucleus of the hypothalamus plays an important role in the control of erectile function and sexual activity. As the male rat is a model of sexual behaviour and penile physiology, which has largely increased in the last years our knowledge of peripheral and central mechanisms controlling erectile function (drugs that induce penile erection in male rats usually do so also in man), the above results may have great significance in terms of a human perspective for the treatment of erectile dysfunction.

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Old 11-26-2010, 12:36 PM
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Considered by Muscle Warfare researchers....
Thats just great Klosey. That made me smile.
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Old 11-26-2010, 01:41 PM
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Considered by Muscle Warfare researchers....
Thats just great Klosey. That made me smile.
lol its true though.. those guys are bigging this stuff up like it will replace steroids...
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Old 12-02-2010, 09:58 PM
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So far DAA seems pretty solid, I haven't tried it yet, though. Waiting for some more research to be done and also to hear more feedback on this product.
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Old 12-11-2010, 03:29 PM
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Latest feedback on this item suggests its delivery problem has been sorted. the DAA is slightly high PH wise when mixed with water, Many are finding bicarbonate soda helps with this.. a mix of 2:1 DAA : bicarb seems to work well and is showing to increse effectiveness of the DAA.
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Old 12-26-2010, 03:52 AM
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Originally Posted by klosey View Post
Latest feedback on this item suggests its delivery problem has been sorted. the DAA is slightly high PH wise when mixed with water, Many are finding bicarbonate soda helps with this.. a mix of 2:1 DAA : bicarb seems to work well and is showing to increse effectiveness of the DAA.
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Old 01-10-2011, 04:20 PM
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What will you suggest to be the optimal daily dosage for DAA?
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Old 01-10-2011, 04:26 PM
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What will you suggest to be the optimal daily dosage for DAA?
around 5g a day
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Old 05-23-2011, 09:45 PM
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what about the safety ?

Is it advised to cycle or can you take it continueously?
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Old 05-24-2011, 07:17 AM
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Quote:
Originally Posted by paraman View Post
what about the safety ?

Is it advised to cycle or can you take it continueously?
Cycle... however length of cycle is debatable.... it was cycled in study 12 days on, 12 days off... however i am aware of the following

1. 6 week cycles and 4 week breaks between
2. Pulsing 5 days on 2 days off for 10 weeks
3. 21 day cycle
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