Disruption of BCATm leads to increased energy expendature - ABCbodybuilding

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Old 10-09-2007, 06:16 PM
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Default Disruption of BCATm leads to increased energy expendature

1: Cell Metab. 2007 Sep;6(3):181-94.Click here to read Links
Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.
She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM.

Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Leucine is recognized as a nutrient signal; however, the long-term in vivo consequences of leucine signaling and the role of branched-chain amino acid (BCAA) metabolism in this signaling remain unclear. To investigate these questions, we disrupted the BCATm gene, which encodes the enzyme catalyzing the first step in peripheral BCAA metabolism. BCATm(-/-) mice exhibited elevated plasma BCAAs and decreased adiposity and body weight, despite eating more food, along with increased energy expenditure, remarkable improvements in glucose and insulin tolerance, and protection from diet-induced obesity. The increased energy expenditure did not seem to be due to altered locomotor activity, uncoupling proteins, sympathetic activity, or thyroid hormones but was strongly associated with food consumption and an active futile cycle of increased protein degradation and synthesis. These observations suggest that elevated BCAAs and/or loss of BCAA catabolism in peripheral tissues play an important role in regulating insulin sensitivity and energy expenditure.
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Old 10-10-2007, 05:15 AM
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Default Re: Disruption of BCATm leads to increased energy expendature

That study is awesome, Layne. I was talking to Jake about that today, and he is pumped. Hopefully he'll have time to come on here and give his thoughts.
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Old 10-10-2007, 01:50 PM
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Default Re: Disruption of BCATm leads to increased energy expendature

That is very interesting. Layne, what are your thoughts on mechanisms?

A few that come to mind include (1) a higher anabolic stimulus for muscle tissue. I am not positive on the experimental conditions lean tissue outcomes in the study, but predictably with higher levels of BCAAs they should have a greater stimulus for muscle growth, greater lean tissue with a subsequent (A) greater capacity to handle a given glucose load. For example much of the variance in weight training's capacity to improve glucose tolerance is lean tissue based.

(2) The higher stimulus for protein synthesis from the BCAAs would in and of itself stimulate greater energy expenditure as this is a highly metabolically costly process.

(3) leucine also lowers the oxidation of pyruvate by inhibiting its rate limiting enzyme pyruvate dehydrogenase and partitions it towards the glucose alanine cycle. This could also assist in maintaining stable blood glucose levels.

Finally, this seems to be in line with a lot of the research your lab has done comparing diets with a 3.5 to 1 ratio of carbohydrates to protein vs. a 1.5 to 1 ratio, in that the latter was associated with improved glucose and insulin tolerance



Layman DK, Baum JI. Dietary protein impact on glycemic control during weight loss. J Nutr. 2004 Apr;134(4):968S-73S.
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Old 10-10-2007, 03:07 PM
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Default Re: Disruption of BCATm leads to increased energy expendature

So is this study saying that perhaps sipping BCAA's throughout the day could indirectly cause one to burn MORE calories?

I LOVE my sciviation Xtend, and would love to hear it is a good thing to drink ALL DAY long!!
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Old 10-10-2007, 03:48 PM
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Default Re: Disruption of BCATm leads to increased energy expendature

No, its definitely not optimal to have protein all day long. In a nut shell, if you keep protein levels constantly elevated the protein synthetic machinery goes "refractory" and you no longer will stimulate protein synthesis. It appears you have to let amino acid levels drop first, and then spike them again with a meal to stimulate anabolism.
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Old 10-10-2007, 07:52 PM
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Default Re: Disruption of BCATm leads to increased energy expendature

so what is the study proving that we didn't already know? Isn't it pretty common knowledge that we need to eat protein every 2-3 hours throughout the day?

sorry not trying to come across rude or anything, just trying to make sense of the study....
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Old 10-10-2007, 08:06 PM
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Default Re: Disruption of BCATm leads to increased energy expendature

It really has nothing to do with optimal protein prescriptions or optimal protein frequency. It is more basic and mechanistic research telling us further benefits which can be attributed to amino acid supplementation.

It also refutes some theories which proposed that high levels of bcaas would have the opposite effect on insulin sensitivity and glucose regulation.
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