Verdict on NO2

[LudStrike4]

I tried NO2 recently after getting a free sample. I didn't really feel any different except maybe a little larger pump. My question is, what's the final verdict on this suppliment. Is it safe? Effective? I can't find any facts about it, only advertisments from companies trying to sell it. Does anybody else have any personal experience with NO2?

[NJI]

[ QUOTE ]
Yu Yevon said:
The study focuses on nitric oxcide synthesis and its effect on vasodilatation. At first it seems that science backs no2, but upon further inspection you will see that no2 is actually quite dangerous.
The study:
Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.
Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ.
Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands.

BACKGROUND: The role of endothelin (ET)-1 in maintenance of basal vascular tone has been demonstrated by local and systemic vasodilatation to endothelin receptor antagonists in humans. Although the constrictor effects mediated by the vascular smooth muscle ET(A) receptors are clear, the contribution from endothelial and vascular smooth muscle ET(B) receptors remains to be defined. The present study, in human forearm resistance vessels in vivo, was designed to further investigate the physiological function of ET(A) and ET(B) receptor subtypes in human blood vessels and determine the mechanism underlying the vasodilatation to the ET(A)-selective receptor antagonist BQ-123. METHODS AND RESULTS: Two studies were performed, each in groups of eight healthy subjects. Brachial artery infusion of BQ-123 caused significant forearm vasodilatation in both studies. This vasodilatation was reduced by 95% (P=.006) with inhibition of the endogenous generation of nitric oxide and by 38% (P<.001) with coinfusion of the ET(B) receptor antagonist BQ-788. In contrast, inhibition of prostanoid generation did not affect the response to BQ-123. Infusion of BQ-788 alone produced a 20% reduction in forearm blood flow (P<.001). CONCLUSIONS: Selective ET(A) receptor antagonism causes vasodilatation of human forearm resistance vessels in vivo. This response appears to result in major part from an increase in nitric oxide generation. ET(B) receptor antagonism either alone or on a background of ET(A) antagonism causes local vasoconstriction, indicating that ET(B) receptors in blood vessels respond to ET-1 predominantly by causing vasodilatation.
PubMed

Here lies the problem; vasodilatation causes a drop in blood pressure (because as the veins widen, the pressure drops). Baroreceptors in the aortic arch and in the carotid sinus will detect this fast, sudden drop. In order to protect the body from going into shock, vasomotor centers in the medulla will cause the blood vessels to the brain to constrict in order to increase blood pressure going into the brain (too much blood can severely damage the brain, just like too little). This is a dangerous sequence that can potentially lead to catastrophe!

Keep this in mind the next time you consider using any supplement that claims prolonged pump due to nitric oxide synthesis.
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Quote:
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Yu Yevon said:
Here are some links to the effects of nitric oxide synthesis:
http://www.imakerala.org/nitricoxide1.htm
http://www.gla.ac.uk/departments/ibl...002/cardio.htm
http://physiology.cup.cam.ac.uk/Proc...Files/S68.html
http://physiology.cup.cam.ac.uk/Proc...Files/S63.html
http://physiology.cup.cam.ac.uk/Proc...Files/S71.html
http://physiology.cup.cam.ac.uk/Proc...Files/S72.html
http://physiology.cup.cam.ac.uk/Proc...Files/S73.html
http://physiology.cup.cam.ac.uk/Proc...Files/S74.html
http://physiology.cup.cam.ac.uk/Proc...Files/S75.html
http://physiology.cup.cam.ac.uk/Proc...Files/S76.html
http://physiology.cup.cam.ac.uk/Proc...Files/S78.html
http://content.nejm.org/cgi/content/short/328/23/1659
http://ehpnet1.niehs.nih.gov/docs/19.../abstract.html
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Quote:
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My advice would be to stop taking it at once. I can find the medical studies to back my claim from the American Journal of Sports Medicine, the Journal of Applied Physiology and the National Strength and Conditioning Journal.

But I will simplify it for you:

<font color="red"> Nitric oxcide (no2) causes vasodilation in your blood vessels. As a result, blood pressure drops quickly and drastically. This alerts chemoreceptors and as a last ditch effort to keep the brain from going into shock, the blood vessels leading to the brain vasoconstrict (tighten/get smaller). Sometimes the blood vessels contract completely, not allowing any blood to get through to the brain.
It is no wonder why the most common side effect of no2 is dizzyness. Some have fainted and some have died. I suspect more deaths will come from no2 in the near future. Make sure you aren't one of them...

[/ QUOTE ] </font>

[thatman]

I do love the knowledge of the mods!!! [img]/forum/images/graemlins/smile.gif[/img]

[Anaxibius]

Holy shnikey's I am impressed with these guys.

[LegendaryWatcher]

You received a free sample and were expecting to see results from one day of usage? It even says in their claims that it takes up to five days to see results. Who knows, all I know is that I have read that it is not good for you. I have never tried the straight up N02 products.

[TheShanMan]

I recently got one of those free samples too, and it went straight into the garbage thanks to the knowledge I've gained by hanging out here. Thanks to the best BB site on the net and to the wonderful mods for taking so much time to share their knowledge. [img]/forum/images/graemlins/smile.gif[/img]

[aussie_muscle]

^^Yep they are great.

No joke I have learn't more here in the time i've been here then I have at school for 13 years. I, personally, and many other ABC'ers cant thank you mods enough for all the info and dedication to bring us info. You have helped me so much and have actually turned me against junk food. I now hate it. The recipes here are much better. Thanks guys. [img]/forum/images/graemlins/grin.gif[/img]

Yer NO2 sux. I had a friend who took it for a while. It did nothing and actually gave him diarea for a good while.

Aussie.

[rev]

I've tried NO2 (it was before I discovered abc, don't kill me mods!). It's just a cute trick to keep you pumped for long periods of time, but it doesn't really do anything for you in the long run. I've heard people call creatine "fake muscles", but this stuff is the real fake muscles. It's a pain in the [*%#*%*#], you have to take it before meals, you have to keep your water intake up, it's expensive as hell, it's just not all they hype it up to be. Then I learned what Yu stated above and was glad I'd stopped taking it. Trust me, I've used it, it's poop, spend your money on whey protein and creatine instead.

[Adam Knowlden]

Joe is the man!

Just wait guys! We haven't even started yet!!!

[RawIron]

Used the whole bottle. It did NOTHING!