ABCbodybuilding - View Single Post - Optimizing Muscle Protein Synthesis
View Single Post
  #6  
Old 05-04-2009, 10:49 PM
President Wilson's Avatar
President Wilson President Wilson is offline
President Wilson is hard at work
Administrator
 
Join Date: Apr 2001
Location: California
Posts: 11,582
Default

Great post! The first study was very interesting, particularly in the older adult rats demonstrating that CHO had greater anabaolic effects post prandially than the fat.

Im curious as to what you guys think the mechanisms of each are. I think clearly insulin effects protein synthesis via a PI3-K-AKT-mTOR mechanism, and also via its ability to increase endothelial NO and thus skeletal muscle blood flow. So when combining carbs with amino acids the carbs should amplify the amino acids effects. And of course we know CHO has big time effects on protein breakdown.

Fats on the other hand arent so obvious to me. For one they may elivate certian anabolic hormones such as testosterone, and secondly it is possible that just by virtue of added substrate that they may spare the oxidation of amino acids
__________________
Dr. Jacob Wilson, Ph.D, CSCS
President Abcbodybuilding.com
Professor of Exercise Science, University of Tampa Bay

About me --> http://www.abcbodybuilding.com/presidentprofile.html
Reply With Quote