Re: How to Optimize Fat Efficiency in the Diet Part II - Essential Fats
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Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU study.
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Heres another study I found relevant. It is one of the few well designed (large and long term) human trials on insulin sensitivity/n-3FAs. There are a number showing non-results in human studies as regards insulin sensitivity.
This one indicates that n-3 supplementation (2.4g/d EPA/DHA) increased sensitivity, but ONLY in the subjects with <37% of calories from fats. This improved sensitivity 20% when ~10% of the dietary fat was switched from saturated to mono-unsaturated (n-3)!