Antioxidants prevent health-promoting effects of physical exercise in humans
 

this is a paper i'm presenting on this week...found it to be very interesting...i've never been one to advocate anti-oxidant supplementation, and this sure helps my case

http://www.pubmedcentral.nih.gov/pic...0&blobtype=pdf

i'd be curious to what you guys thought about this...i know ALA which is an anti-oxidant has been shown to induce HSP's in those fed a High fat diet...but not in chow diet...this got me thinking...the dose of ALA was 30mg/kg which is a very high dose...so i'm just throwing this out there(haven't read the ALA study in a while, just going by memory)...could they possibly have dosed it so high that the insulin sensitivity they saw in there study was due not to ALA but to the ROS formed from the anti-oxidant turning pro-oxidative? idk, honestly i have a hundred things going through my brain right now, but i can't stop thinking about this...maybe it makes no sense what so ever...any thoughts?

i want the study expanding i noticed the reduced ros formation existed in there opinion for the first three days of supplementation atleast, i'm interested to see how the results compare to regular supplementation not just supplementation for study group

there were 2 parts to the study...the second part was daily supplement use for 4 weeks

Anti-oxidants are somewhat baffling. I have seen several studies show ALA improves insulin sensitivity in diabetics; and that anti-oxidants can improve muscle protein synthesis, particularly in elderly populations.

It may be the case of acute vs. chronic. As is the case with acidity - blunting chronic acidity by consuming certain foods appears to increase protein synthesis. But bluting the acidic response during/after exercise attenuates the release of growth factors.

So maybe the studies that show benefits are for those who have chronic oxidative stress - elderly, obese, diabetic - but perhaps one bout of oxidative stress daily, in healthy young pops as your study examined, is good?

Kind of the case of a good stresser, versus a bad stresser. And finding the line between the two.

Not sure, just throwing something out there.

i definitely think acute vs chronic plays a huge role

That would be a worthy subject of doing a critical review article on. Similar to my HMB review.

i like where your heads at Mr. Wilson :) i might try and see if i can't make something happen