matpal
02-18-2009, 06:55 PM
Trinitine?
Possibly the greatest Creatine advancement since regular MCC??
Since its rapid rise in popularity in the 1990s, consumers and health enthusiasts alike have marveled at the wonders of creatine. Championed as the best-studied sports supplement ingredient, its reputation has vast amounts of support. However, this research continues to center on creatine monohydrate while neglecting various postulated creatine salts, which may hold additional ergogenic benefit.
One such salt, Magnesium Creatine Chelate (MCC), introduced to the industry by Albion Labs?, has shown such promise while many of the alternative salts lack research support. Still, MCC alone is not without its own potential flaws that could render it less efficacious than it could be. As a result, the collective proposal of three creatine chelate salts holds potential to revolutionize a concept that will propel it to the forefront of the sports supplement industry.
Magnesium Creatine Chelate (MCC)
The first of three components to the Trinitine? Complex, Magnesium Creatine Chelate (MCC) has been show in studies to improve exercise performance and allows athletes to reach exhaustion later in their exercise routine. This patented ingredient by Albion Labs is highly bioavailable and offers protection from the digestive tract. Protection from destruction in the digestive tract is crucial because it will make more creatine available for absorption in the body.
Eight percent of MCC is elemental magnesium. Magnesium is a macromineral that has many synergistic effects with creatine. In fact, ATP is actually found in the muscle cells bound to magnesium for stability. Taken on its own, magnesium has been shown to enhance strength and energy levels. It is intimately involved in the energy (Kreb?s) cycle and has cardio-protective effects as well.
Creatine monohydrate has been shown to be very effective in hundreds of studies; however some users experience stomach discomfort due to lower absorption rate and breakdown into its by-product creatinine in the stomach. By creating a creatine-magnesium chelate, creatine can be protected from the harsh environment of the stomach acid and this chelate can help prevent breakdown. It can also help enhance absorption of creatine and decrease stomach discomfort that many creatine users (and their friends) can appreciate. This chelation provides a highly bioavailable form of creatine and magnesium.
Initial research shows MCC is better absorbed and tolerated than traditional creatine monohydrate supporting more explosive gains in muscle size, strength, and endurance. Further still, when compared with creatine monohydrate groups and various magnesium salts, you also get significant increased levels of absorption with the MCC than either component alone. As a result, you harness the ergogenic power of both creatine and magnesium:
Supercharging strength and power output
Prolonging endurance activity
Speeding muscle recovery
Reducing fatigue
Increasing muscle size and volumization
Enhancing ATP preservation and recovery
Maximizing creatine storage and uptake into muscle
It also mixes well in water. There have been no side effects shown with this compound at the recommended doses and it shows excellent promise for the future of creatine.
Still, there is one potential consideration that must be considered with various ions added into the equation. A potential offset of the homeostatic mechanisms will render the entire process useless if taken out of significant proportion. If magnesium concentration is higher than that of ATP, magnesium inhibited the ATPase and simultaneously stimulated the phosphatase. Increasing the concentration of magnesium directly causes a change in the conformation of the enzyme which favors ATPase activity to one which favors phosphatase activity.
http://img34.picoodle.com/img/img34/3/2/18/f_graphm_3206474.jpg
The potential remedy to this potential downfall lies in a sodium and potassium ratio that would offset potential inactivation of the ATPase. Enter KCC and NaCC?
Potassium Creatine Chelate (KCC) and Sodium Creatine Chelate (NaCC)
Primary active transport carriers are often referred to as pumps. Although some of these carriers transport only one molecule or ion at a time, others exchange one molecule or ion for another. The most important of this latter type of carrier is the Na+/K+-ATPase or pump. This carrier protein, which is also an ATPase enzyme that converts ATP to ADP + Pi, actively extrudes three sodium ions (Na+) from the cell as it transports two potassium ions (K+) into the cell. The transport is energy dependent because Na+ is more highly concentrated outside the cell and K+ is more concentrated within the cell. Both ions, in other words, are moved against their concentration gradients.
http://img02.picoodle.com/img/img02/3/2/18/f_nakpumpm_6d76532.jpg
Most cells have numerous Na+/K+ pumps that are constantly active. For example, there are about 200 Na+/K+ pumps per red blood cell, about 35,000 per white blood cell, and several million within the tubules of the kidney. This represents an enormous expenditure of energy used to maintain a steep gradient of Na+ and K+ across the cell membrane. This steep gradient serves four functions:
[1] the steep Na+ gradient is used to provide energy for the coupled transport of other molecules
[2] the activity of the Na+/K+ pumps can be adjusted (primarily by thyroid hormones) to regulate resting calorie expenditure and basal metabolic rate of the body
[3] the Na+ and K+ gradients across the cell membranes of nerve and muscle cells are used to produce electrochemical impulses needed for the functions of the nerves and muscles, including the heart
[4] the active extrusion of Na+ is important for osmotic reasons controlling fluid regulation of muscle cells. If the pumps stopped functioning, the increased Na+ concentration within cells would promote the osmotic inflow of water and damage the cells.
Endogenous Regulation
The Na+/K+-ATPase is thought to be downregulated by cAMP, therefore substances causing an increase in cAMP downregulates the Na+/K+-ATPase.
In contrast, substances causing a decrease in cAMP upregulates Na+/K+-ATPase. Still, cAMP acts as a second messenger which causes an increase in protein abundance of Na+/K+-ATPase.
Exogenous Regulation
There is a Na+/Ca2+ translocator which uses the sodium gradient generated by the Na/K-ATPase to remove Ca2+ from the intracellular space and slowing down the Na+/K+-ATPase results in a predominantly higher Ca2+ level in the muscle which will eventually lead to stronger contractions.
Efficacy of NaCC/KCC
The first point of potential criticism might be why MCC was chosen rather than many of the new esterified creatines showing up on the market at a precipitous rate. The answer is simple if you are not one of the science types to care for the presentation above. Rather than being completely dictated by supply-side ingredient lists, the important take home message is that MCC is, without a doubt, a step in the right direction and the only creatine salt with any data supporting its potential superiority to creatine monohydrate ? though not without room for improvement.
Trinitine,? with its exclusive Sodium and Potassium Creatine Chelates offset this shortcoming and initial data on the combination of the three chelates in combination is nothing short of amazing magnifying all of the effects of MCC alone.
And, it doesn?t stop there. To maximize creatine uptake by creatine receptors, research has shown that insulin or sodium are required. Many supplement companies have subsequently suggested taking creatine with copious tallies of fast-acting carbohydrates such as simple sugars to boost insulin levels and therefore maximize creatine uptake by muscle cells.
Unfortunately, this protocol sacrifices body composition goals of a nation where over two-thirds do NOT handle carbohydrates well and while taking them pre-workout in any significant quantity required to do this, you set-up a hormonal prescription that will not agree with favorable body composition change.
Decreased GH and subsequently IGF-1
Decreased catecholamines (epinephrine, norepinephrine, dopamine)
Decreases insulin-sensitivity for anabolic priming post-workout
Does NOT allow for appropriate glycogen-depletion states
Not to mention, carbohydrates are very cheap and unnecessary despite ad proclamation to the contrary. Sodium actually trumps carbohydrates in the creatine uptake department by helping keep the amount of creatine receptors maximized which is the key to continued creatine efficacy over the long-haul.
...
Possibly the greatest Creatine advancement since regular MCC??
Since its rapid rise in popularity in the 1990s, consumers and health enthusiasts alike have marveled at the wonders of creatine. Championed as the best-studied sports supplement ingredient, its reputation has vast amounts of support. However, this research continues to center on creatine monohydrate while neglecting various postulated creatine salts, which may hold additional ergogenic benefit.
One such salt, Magnesium Creatine Chelate (MCC), introduced to the industry by Albion Labs?, has shown such promise while many of the alternative salts lack research support. Still, MCC alone is not without its own potential flaws that could render it less efficacious than it could be. As a result, the collective proposal of three creatine chelate salts holds potential to revolutionize a concept that will propel it to the forefront of the sports supplement industry.
Magnesium Creatine Chelate (MCC)
The first of three components to the Trinitine? Complex, Magnesium Creatine Chelate (MCC) has been show in studies to improve exercise performance and allows athletes to reach exhaustion later in their exercise routine. This patented ingredient by Albion Labs is highly bioavailable and offers protection from the digestive tract. Protection from destruction in the digestive tract is crucial because it will make more creatine available for absorption in the body.
Eight percent of MCC is elemental magnesium. Magnesium is a macromineral that has many synergistic effects with creatine. In fact, ATP is actually found in the muscle cells bound to magnesium for stability. Taken on its own, magnesium has been shown to enhance strength and energy levels. It is intimately involved in the energy (Kreb?s) cycle and has cardio-protective effects as well.
Creatine monohydrate has been shown to be very effective in hundreds of studies; however some users experience stomach discomfort due to lower absorption rate and breakdown into its by-product creatinine in the stomach. By creating a creatine-magnesium chelate, creatine can be protected from the harsh environment of the stomach acid and this chelate can help prevent breakdown. It can also help enhance absorption of creatine and decrease stomach discomfort that many creatine users (and their friends) can appreciate. This chelation provides a highly bioavailable form of creatine and magnesium.
Initial research shows MCC is better absorbed and tolerated than traditional creatine monohydrate supporting more explosive gains in muscle size, strength, and endurance. Further still, when compared with creatine monohydrate groups and various magnesium salts, you also get significant increased levels of absorption with the MCC than either component alone. As a result, you harness the ergogenic power of both creatine and magnesium:
Supercharging strength and power output
Prolonging endurance activity
Speeding muscle recovery
Reducing fatigue
Increasing muscle size and volumization
Enhancing ATP preservation and recovery
Maximizing creatine storage and uptake into muscle
It also mixes well in water. There have been no side effects shown with this compound at the recommended doses and it shows excellent promise for the future of creatine.
Still, there is one potential consideration that must be considered with various ions added into the equation. A potential offset of the homeostatic mechanisms will render the entire process useless if taken out of significant proportion. If magnesium concentration is higher than that of ATP, magnesium inhibited the ATPase and simultaneously stimulated the phosphatase. Increasing the concentration of magnesium directly causes a change in the conformation of the enzyme which favors ATPase activity to one which favors phosphatase activity.
http://img34.picoodle.com/img/img34/3/2/18/f_graphm_3206474.jpg
The potential remedy to this potential downfall lies in a sodium and potassium ratio that would offset potential inactivation of the ATPase. Enter KCC and NaCC?
Potassium Creatine Chelate (KCC) and Sodium Creatine Chelate (NaCC)
Primary active transport carriers are often referred to as pumps. Although some of these carriers transport only one molecule or ion at a time, others exchange one molecule or ion for another. The most important of this latter type of carrier is the Na+/K+-ATPase or pump. This carrier protein, which is also an ATPase enzyme that converts ATP to ADP + Pi, actively extrudes three sodium ions (Na+) from the cell as it transports two potassium ions (K+) into the cell. The transport is energy dependent because Na+ is more highly concentrated outside the cell and K+ is more concentrated within the cell. Both ions, in other words, are moved against their concentration gradients.
http://img02.picoodle.com/img/img02/3/2/18/f_nakpumpm_6d76532.jpg
Most cells have numerous Na+/K+ pumps that are constantly active. For example, there are about 200 Na+/K+ pumps per red blood cell, about 35,000 per white blood cell, and several million within the tubules of the kidney. This represents an enormous expenditure of energy used to maintain a steep gradient of Na+ and K+ across the cell membrane. This steep gradient serves four functions:
[1] the steep Na+ gradient is used to provide energy for the coupled transport of other molecules
[2] the activity of the Na+/K+ pumps can be adjusted (primarily by thyroid hormones) to regulate resting calorie expenditure and basal metabolic rate of the body
[3] the Na+ and K+ gradients across the cell membranes of nerve and muscle cells are used to produce electrochemical impulses needed for the functions of the nerves and muscles, including the heart
[4] the active extrusion of Na+ is important for osmotic reasons controlling fluid regulation of muscle cells. If the pumps stopped functioning, the increased Na+ concentration within cells would promote the osmotic inflow of water and damage the cells.
Endogenous Regulation
The Na+/K+-ATPase is thought to be downregulated by cAMP, therefore substances causing an increase in cAMP downregulates the Na+/K+-ATPase.
In contrast, substances causing a decrease in cAMP upregulates Na+/K+-ATPase. Still, cAMP acts as a second messenger which causes an increase in protein abundance of Na+/K+-ATPase.
Exogenous Regulation
There is a Na+/Ca2+ translocator which uses the sodium gradient generated by the Na/K-ATPase to remove Ca2+ from the intracellular space and slowing down the Na+/K+-ATPase results in a predominantly higher Ca2+ level in the muscle which will eventually lead to stronger contractions.
Efficacy of NaCC/KCC
The first point of potential criticism might be why MCC was chosen rather than many of the new esterified creatines showing up on the market at a precipitous rate. The answer is simple if you are not one of the science types to care for the presentation above. Rather than being completely dictated by supply-side ingredient lists, the important take home message is that MCC is, without a doubt, a step in the right direction and the only creatine salt with any data supporting its potential superiority to creatine monohydrate ? though not without room for improvement.
Trinitine,? with its exclusive Sodium and Potassium Creatine Chelates offset this shortcoming and initial data on the combination of the three chelates in combination is nothing short of amazing magnifying all of the effects of MCC alone.
And, it doesn?t stop there. To maximize creatine uptake by creatine receptors, research has shown that insulin or sodium are required. Many supplement companies have subsequently suggested taking creatine with copious tallies of fast-acting carbohydrates such as simple sugars to boost insulin levels and therefore maximize creatine uptake by muscle cells.
Unfortunately, this protocol sacrifices body composition goals of a nation where over two-thirds do NOT handle carbohydrates well and while taking them pre-workout in any significant quantity required to do this, you set-up a hormonal prescription that will not agree with favorable body composition change.
Decreased GH and subsequently IGF-1
Decreased catecholamines (epinephrine, norepinephrine, dopamine)
Decreases insulin-sensitivity for anabolic priming post-workout
Does NOT allow for appropriate glycogen-depletion states
Not to mention, carbohydrates are very cheap and unnecessary despite ad proclamation to the contrary. Sodium actually trumps carbohydrates in the creatine uptake department by helping keep the amount of creatine receptors maximized which is the key to continued creatine efficacy over the long-haul.
...