Topical Fat loss creams

[President Wilson]

Ok guys,

I think this is a very contraversial topic, and many are skepticle I would love to hear what your thoughts and experiences are. What do you think of the use of topical fat loss creams. And what evidence do you have to support their use or non use, both empirically or through studies.

Here is their basic premise

1. Certain agents have a potent lipolytic effect. The basics are as follows

A. Beta agonists - these mimick epinephrine and norepinephrine by binding to the same receptors that these hormones bind to. When binding occurs E and NE stimulate a secondary messenger (cAMP) which in turn leads to the activation of an enzyme which degrades triglycerides into fatty acids (breaks down fat tissue). Ephedra is your classic supp here, but there are others like synepinephrine which is in common use now

B. Phosphodiesterase inhibitors - phosphodiesterase is the enzyme which breakds down cAMP. By hindering this enzyme you effectively prolonge the effects of the beta agonist.

Caffiene is typically used here

C. Alpha antagonists - E and NE can also bind to alpha receptors which hinder fat breakdown. But alpha antagonists block these receptor sites so that E and NEs effects on fat breakdown are unopposed. The common supp here is yohimbe

D. Agents which stop the breakdown of E and NE - Here grean tea is used as it contains epigallocatechin-3-gallate (EGCG)

This stops the enzyme which degrades E and NE.

The rationale is that by applying these agents in a topical or cream format that you can directly target the area of fat to be metabolized, hence 'spot reducing'

Once that term gets introduced people become skeptacle. So what are your insights?

[iLLa]

i know nothing about this and i am extremely skeptical. i would think that its not dif from taking ephedra. i would think that once its absorbed through the skin it would be circulating through the blood stream. but then again what do i know, if you put on icyhot it targets one area for muscles.

[book]

I don't see how it could penetrate far enough..It'd have to cross 2 layers of dense skin then also I assume be able to effectively diffuse throughout the fat cells.

With that said I have used a topical "injury supplement" that seemed to help, but cannot chalk all my recovery to it since I was getting physiotherapy/resting the injury as well.

[Venom]

I would like to hear more about this, too.

What I will say, is that even if it does work, I would not consider investing money into it, unless you already are taking all the core supplements, such as glutamine, creatine, and essential amino acids. Otherwise, your money is not being spent wisely. But if you are, and can afford to purchase another supplement, then you could consider this.

[ QUOTE ]

I don't see how it could penetrate far enough..It'd have to cross 2 layers of dense skin then also I assume be able to effectively diffuse throughout the fat cells.

[/ QUOTE ]

Great point!

Do you think it would be more effective if you are lean, or, on areas that tend to store less fat (e.g. your calves and face)?

[book]

[ QUOTE ]
I would like to hear more about this, too.

What I will say, is that even if it does work, I would not consider investing money into it, unless you already are taking all the core supplements, such as glutamine, creatine, and essential amino acids. Otherwise, your money is not being spent wisely. But if you are, and can afford to purchase another supplement, then you could consider this.

[ QUOTE ]

I don't see how it could penetrate far enough..It'd have to cross 2 layers of dense skin then also I assume be able to effectively diffuse throughout the fat cells.

[/ QUOTE ]

Great point!

Do you think it would be more effective if you are lean, or, on areas that tend to store less fat (e.g. your calves and face)?

[/ QUOTE ]

Well I remember a member a long time ago claimed to see results with a yohimbe cream. Personally, with all fat loss supplements, I don't think any noticeable results can be seen unless it's a very potent stimulant/a combination of various stimulants and thermogenics. Why not be a human guinea pig Venom /forum/images/graemlins/wink.gif

[dashforce]

He is -- He's jumping on the experimental AD bandwagon with me and Calvin!!

Not sure about the creams, though. I tried looking up synepinephrine (mentioned in the Pres's introductory post) and can't find anything anywhere on it ("Your search - synepinephrine - did not match any documents." -- google). Am I spelling it right?

[Venom]

http://www.bulknutrition.com/?products_id=875

The reviews on that site are pretty positive.

Hey, book

I just might do that haha!

[Ignoramus]

if there was such a product that worked, wouldnt it explode on the market like creatine?

[didymus]

[ QUOTE ]
He is -- He's jumping on the experimental AD bandwagon with me and Calvin!!

Not sure about the creams, though. I tried looking up synepinephrine (mentioned in the Pres's introductory post) and can't find anything anywhere on it ("Your search - synepinephrine - did not match any documents." -- google). Am I spelling it right?

[/ QUOTE ]
It is actually synephrine (not epinephrine), if I recall correctly.

[dashforce]

You're right, I found it yesterday. Both the Pres and I spelled it wrong (whups). I didn't find a whole lot of info on it, though -- just seems like another ephedrine wanna-be basically.

[rickck48]

I read the site you posted. I saw all these added ingredients to the cream, as a novice what would these items be doing as for as stimulating fat burn? In addition to Yohimbine, each bottle of Lipoderm-ULTRA contains:

Lecithin
Sesamin
Caffeine
Octopamine
Synephrine HCl
ALCAR
Ascorbyl Palmitate
Each 4oz bottle contains 30-60 applications.

Sounds like a lot of applications for a 4oz. bottle? /forum/images/graemlins/confused.gif

[Ignoramus]

it burns a hole in your wallet, which in turn leaves less money for food. Ta da! ure thinner.

[book]

[ QUOTE ]
it burns a hole in your wallet, which in turn leaves less money for food. Ta da! ure thinner.

[/ QUOTE ]

lolol

[Qester]

I have no personal experience with it. A friend of mine who works for muscletech says that the creams are bogus (I dont believe muscle tech actually makes any though). Yet another one of my friends who lives a bodybuilding lifestyle swears by it, and hes gotten pretty lean.

[LeoDeSol]

Just do like Howie does in The Benchwarmers to help protect him from the sun.

Eat the cream lol.





***this is a joke, please don't eat this stuff***

[dashforce]

Here's an article covering a few topical creams...

http://www.mindandmuscle.net/mindandmuscle/magpage.php?issueID=3&artID=99915

[ShowKidd]

[ QUOTE ]
it burns a hole in your wallet, which in turn leaves less money for food. Ta da! ure thinner.

[/ QUOTE ]

shhhh you are giving up the supplement companys secrets.lol